It is indicated in the treatment of pneumonia, septicaemia, Meningitis, skin and soft tissue infections, infections in neutropenic patients, Gonorrhoea, periopeartive prophylaxis of infections associated with surgery.
- Solutions in lignocaine should not be given intravenously.
- Syceph should not be given to neonates with jaundice or those who are hyperalbuminaemic or acidotic or have other conditions such as prematurity.
- Anaphylactic shock requires immediate counter measures.
Dosage & Administration
Adults and children 12 years and over: 1g once daily. In severe infections, 2-4g once daily.
Children under 12 years:
20-50mg/kg body weight once daily. Up to 80mg/kg body weight may be given in severe infections. Children with body weight of 50kg or more, the usual dosage should be used. Doses of 50mg/kg or over should be given by slow intravenous infusion over at least 30 minutes.
Intramuscular Injection: 1g Syceph should be dissolved in 3.5ml of 1% Lignocaine hydrochloride injection B.P and administered by deep 1.m injection.
Doses greater than 1g should be divided and injected at more than one site.
Intravenous Injection: 1g Syceph should be dissolved in 10ml of water for injections B.P. The injection should be administered over at least 2-4 minutes directly into the vein or via the tubing of an intravenous infusion.
Syceph has generally been well tolerated. Adverse reactions are usually mild and transient. The most common side effects are diarrhea, nausea and vomiting stomatitis, glossitis, rash, pruritus, uriticaria, oedema and allergic dermatitis.
Pregnancy and lactation
The safety of Syceph in human pregnancy has not been established, therefore, it should not be used in pregnancy unless absolutly indicated.
Only minimal amounts of Syceph are excreted in breast milk, caution is however advised in nursing mothers.